Shedding weight is usually a very difficult task that faces obese people, especially because the traditional weight-loss drugs don’t give the required uni effect to treat this serious health state, beside that, the home remedies, doing exercise, and, the Diets; may help in weight loss, but also in a very slow rate.
As usual, the scientific research and scientists exert their efforts to produce healthy and useful solves for all problems facing humanity, among that, the recent research studies that gave importance to treat obese people, and one of these studies depends on using a type of nanoparticles that succeeded in combating body fats.
Nearly 1/3 of American people suffer from obesity which is considered one of the top reasons for death, especially in cancer patients states.
Scientists at Massachusetts Institute of Technology (MIT) in U.S.A. prepared a type of nanoparticles that have the ability to deliver the weight loss and fat-fighting materials toward the fat tissues directly.
The trial experiments on overweight mice showed that they have lost nearly 10 % of all body weight within only 25 days.
How to target fat tissue
The study author and his colleagues said that in general, targeting fats occurs through the angiogenesis process (which meaning the formation of new blood vessels), so, it transforms adipose tissue and results in weight loss, While angiogenesis may leave bad effects on other body parts.
Therefore, the study’ teamwork tried to overcome this problem by using nanoparticles and depending on drug-delivery strategy, so, they developed medical and safe nanoparticles and packaged these particles with two drugs, thus the 2 drugs activate PPAR receptors which in turn stimulate the angiogenesis process and adipose tissues transformation, thus shedding weight, without leading to any health disorders to other body parts; because the nanoparticles target the adipose tissues only.
Inject mice with fat-fighting nanoparticles
The researchers Injected these fat-fighting nanoparticles into obese mice, and the results showed that it lost 10 % of its body weight, plus blood lipids test results were in the normal range, such as Triglycerides, HDL cholesterol, and LDL cholesterol.
Plus, as we know that obesity may lead to diabetes because it decreases insulin sensitivity, but the results of using these new nanoparticles showed that it also succeeded in controlling mice’s insulin sensitivity.
besides, there are no bad side effects were appeared on the mice at all when injected with these nanoparticles daily over 25 days.
how to deliver fat-fighting nanoparticles into the body
The scientists injected fat-fighting nanoparticles intravenously; Firstly, to make them more broadly applicable for treating all obese people. Secondly, because it is difficult for these nanoparticles to penetrate the intestine lining.
But more recently, other scientists succeeded in developing some other orally delivered nanoparticles by using transferrin, which helped in facilitating the active transportation of nanoparticles through the intestine lining.
At the end of this study, scientists said that they hope to find more specific and effective nanoparticles to target fat tissues without any side effects and packaging the nanoparticles with approved and lower toxicity drugs to get new, healthier, and more effective fat-fighting drug very soon.
The success of nanoparticles in shedding weight by 10 % of mice is a great result, let us apply it theoretically on a person whose body weight is 150 kg; if this results applied, he nearly can lose 15 kg in one month easy without dieting or exercise, but surely, these study results need more research and must be applied on clinical trials with safe nanoparticles and safe overloaded drugs before using it in treating obese people.
This article might interest you as well: Natural Protein offers Novel Therapy for Obese People